El Mostrador y Neurocientíficos de U. de Valparaíso lanzan “Los misterios del cerebro”: Novedades de la neurociencia en el mundo

¿Cree posible que se puedan modificar recuerdos traumáticos, grabados en la memoria por hechos violentos, accidentes o catástrofes, mientras duerme? ¿Ha imaginado un cerebro real, pero perfectamente transparente que permita a los científicos observar con mayor claridad los misterios de la mente? Si nuestras células son como grandes bibliotecas donde cada libro es un gen, ¿piensa que pueda […]

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Structure of an agonist-bound ionotropic glutamate receptor

Ionotropic glutamate receptors (iGluRs) mediate most excitatory neurotransmission in the central nervous system and function by opening their ion channel in response to binding of agonist glutamate. Here, we report a structure of a homotetrameric rat GluA2 receptor in complex with partial agonist (S)-5-nitrowillardiine. Comparison of this structure with the closed-state structure in complex with competitive antagonist ZK 200775 […]

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Survival of Lactobacillus delbrueckii UFV H2b20 in ice cream produced with different fat levels and after submission to stress acid and bile salts

The survival of Lactobacillus delbrueckii UFV H2b20 in three ice cream formulations (low fat, fat free and high fat) was evaluated after the processing and storage at −16 °C. The survival of L. delbrueckii UFV H2b20 was not significantly affected (P > 0.05) in three ice cream formulations after processing. The same result was observed during storage for 40 days at −16 °C. Cells […]

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ROS, innate immunity, and autoimmunity

ROS, reactive oxygen species, are produced by phagocytes and play an essential role in host defense against infection. Recently, scientists discovered the negative regulator of ROS — NRROS. From the study: “NRROS limits the generation of ROS in phagocytes by facilitating the degradation of NOX2 (also known as CYBB), which is a component of the […]

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Overview of Metabolism and Bioavailability Enhancement of Polyphenols

A proper diet is one of major factors contributing to good health and is directly related to general condition of the organism. Phenolic compounds are abundant in foods and beverages (fresh and processed fruits and vegetables, leguminous plants, cereals, herbs, spices, tea, coffee, wine, beer) and their pleiotropic biological activities result in numerous health beneficial effects. On the […]

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Concurso Go To Market – De la idea al mercado

Este concurso tiene como objetivo apoyar la comercialización de tecnologías, provenientes de proyectos de I+D, generar capacidades en emprendimiento y comercialización de resultados de I+D, patentes y tecnologías, junto vincular a los desarrolladores de proyectos de I+D con brokers tecnológicos internacionales para lograr llevar las tecnologías desarrolladas en Chile a mercados globales, generando un ecosistema […]

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Biased ligands at G-protein-coupled receptors: promise and progress

Drug discovery targeting G protein-coupled receptors (GPCRs) is no longer limited to seeking agonists or antagonists to stimulate or block cellular responses associated with a particular receptor. GPCRs are now known to support a diversity of pharmacological profiles, a concept broadly referred to as functional selectivity. In particular, the concept of ligand bias, whereby a […]

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