ROS, innate immunity, and autoimmunity

ROS, reactive oxygen species, are produced by phagocytes and play an essential role in host defense against infection. Recently, scientists discovered the negative regulator of ROS — NRROS. From the study:

“NRROS limits the generation of ROS in phagocytes by facilitating the degradation of NOX2 (also known as CYBB), which is a component of the NADPH oxidase complex. Through NRROS, the production of ROS by phagocytes can be fine-tuned to control invading pathogens while limiting collateral tissue damage.” (1)

This discovery has great significance in autoimmunity research.

Reference:

1. Noubade, R. et. al. (2014) NRROS negatively regulates reactive oxygen species during host defense and autoimmunity. Nature 509, 235.

3_10

Deja una respuesta

Tu dirección de correo electrónico no será publicada. Los campos obligatorios están marcados con *